AkabasLab


NCBI PubMed search of "M.H. Akabas"


    Selected Publications:

  1. Akabas, M.H., Stauffer, D.A., Xu, M., and Karlin, A. (1992) Acetylcholine receptor channel structure probed in cysteine-substitution mutants. Science 258:307-310.
  2. Xu, M., and Akabas, M.H. (1993) Amino acids lining the channel of the gamma-aminobutyric acid type A receptor identified by cysteine-substitution. J. Biol. Chem. 268:21505-21508.
  3. Akabas, M.H., Kaufmann, C., Archdeacon, P., and Karlin, A. (1994) Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the a-subunit. Neuron 13:919-927.
  4. Akabas, M.H., and Karlin, A. (1995) Identification of acetylcholine receptor channel-lining residues in the M1 segment of the a subunit. Biochemistry 34:12496-12500.
  5. Xu, M., Covey, D.F., and Akabas, M.H. (1995) Interaction of picrotoxin with GABAA receptor channel-lining residues probed in cysteine mutants. Biophys. J. 69:1858-1867.
  6. Xu, M. and Akabas, M.H. (1996) Identification of channel-lining residues in the M2 membrane-spanning segment of the GABAA receptor a1 subunit. J. Gen. Physiol. 107:195-205.
  7. Sun, Z.-P., Akabas, M.H., Goulding, E.H., Karlin, A., and Siegelbaum, S.A. (1996) Exposure of residues in the cyclic nucleotide-gated channel pore: P-region structure and function in gating. Neuron 16:141-149.
  8. Cheung, M. and Akabas, M.H. (1996) Identification of CFTR channel-lining residues in and flanking the M6 membrane-spanning segment. Biophys. J. 70:2688-2695.
  9. Cheung, M. and Akabas, M.H. (1997) Locating the anion-selectivity filter of the CFTR chloride channel. J. Gen. Physiol. 109:289-299.
  10. Horenstein, J. and Akabas, M.H. (1998) Location of a high affinity Zn2+ binding site in the channel of a1b1 GABAA receptors. Mol. Pharmacol. 53:870-877.
  11. Akabas, M.H. (1998) Channel-lining residues in the M3 membrane-spanning segment of the cystic fibrosis transmembrane conductance regulator (CFTR). Biochemistry 37:12233-12240.
  12. Guinamard, R. and Akabas, M.H. (1999) Arg352 is a major determinant of charge selectivity in the chloride channel of the cystic fibrosis transmembrane conductance regulator (CFTR). Biochemistry 38:5528-5537.
  13. Williams, D.B. and Akabas, M.H. (1999) GABA increases the water-accessibility of M3 membrane-spanning segment residues in GABAA receptors. Biophys. J. 77:2563-2574.
  14. Williams, D.B. and Akabas, M.H. (2000) Benzodiazepines induce conformational change in the region of the GABAA receptor a1 subunit M3 membrane-spanning segment. Mol. Pharmacol. 58:1129-1136.
  15. Akabas, M.H. (2000) Cystic fibrosis transmembrane conductance regulator: Structure and function of an epithelial chloride channel. J. Biol. Chem. 275:3729-3732.
  16. Horenstein, J., Wagner, D.A., Czajkowski, C. and Akabas, M.H. (2001) Protein mobility and GABA-induced conformational changes detected in the GABAA receptor channel-lining M2 segment. Nature Neurosci. 4:477-485.
  17. Williams, D.B. and Akabas, M.H. (2001) Evidence for distinct conformations of the two a1 subunits in diazepam-bound GABAA receptors. Neuropharmacology 41:539-545.
  18. Reeves, D.C., Goren, E.N., Akabas, M.H. and Lummis, S.C.R. (2001) Structural and electrostatic properties of the 5-HT3 receptor pore revealed by substituted cysteine accessibility mutagenesis. J. Biol. Chem. 276:42035-42042.
  19. Akabas, M.H. (2001) Chloride channels. In: Encyclopedia of Life Sciences. Macmillan Reference Ltd., London.
  20. Williams, D.B. and Akabas, M.H. (2002) Structural evidence that propofol stabilizes different GABAA receptor states at potentiating and activating concentrations. J. Neurosci. 22:7417-7424.
  21. Akabas, M.H., Horenstein, J., Williams, D.B., Bali, M., and Bera, A.K. (2002) GABAA Receptors: Probing the Structural Bases of Function, Gating and Pharmacological Modulation by General Anesthetics. In: Molecular and Basic Mechanisms of Anesthesia. Ed. M. Barann and B.W. Urban. Pabst Science Publishers, Germany. (in press)
  22. Bera, A.K., Chatav, M. and Akabas, M.H. (2002) GABAA receptor M2-M3 loop secondary structure and changes in accessibility during channel gating. J. Biol. Chem. 277:43002-43010.
  23. Bali, M. and Akabas, M.H. (2004) Defining the propofol binding site on the GABAA receptor. Mol. Pharmacol. 65:68-76.
  24. Goren, E.N., Reeves, D.C. and Akabas, M.H. (2004) Loose Protein Packing Around the Extracellular Half of the GABAA Receptor beta1 Subunit M2 Channel-Lining Segment J. Biol. Chem. 279:11198-11206.
  25. Jung, S., Akabas, M.H. and Harris, R.A. (2005) Functional and structural analysis of the GABAA receptor a1 subunit during channel gating and alcohol modulation. J. Biol. Chem. 280:308-316.
  26. Horenstein, J., Riegelhaupt, P. and Akabas, M.H. (2005) Differential Protein Mobility of the GABAA Receptor a and b Subunit Channel-Lining Segments. J. Biol. Chem. 280:1573-1581.
  27. Reeves, D.C., Jansen, M., Bali, M., Lemster, T., Akabas, M.H. (2005) A Role for the beta1-beta2 Loop in the Gating of 5-HT3 Receptors. J. Neurosci. 25:9358-9366.
  28. Akabas, M.H. (2006) Watching single protons bind. Nature Chem. Biol. 2:128-130.
  29. Jansen and Akabas, M.H. (2006) State-Dependent Cross-Linking of the M2 and M3 Segments: Functional Basis for the Alignment of GABAA and Acetylcholine Receptor M3 Segments. J. Neurosci. 26:4492-4499.
  30. Reeves D.C.*, Liebelt D.A.*, Lakshmanan V., Roepe P.D., Fidock D.A., Akabas M.H. (2006) Chloroquine-resistant isoforms of the Plasmodium falciparum chloroquine resistance transporter acidify lysosomal pH in HEK293 cells more than chloroquine-sensitive isoforms. Molec. Biochem. Parasit. 150:288-299. *contributed equally
  31. Qiu, A., Jansen, M., Sakaris, A., Min, S., Chattopadhayay, S., Tsai, E., Sandoval, C., Zhao, R., Akabas, M.H., and Goldman, I.D. (2006) Identification of a proton-coupled intestinal folate transporter and the molecular basis for Hereditary Folate Malabsorption. Cell 127:917-28.
  32. Bali, M. and Akabas, M.H. (2007) The location of a closed channel gate in GABAA receptor channels. J. Gen. Physiol. 129:145-159.
  33. Rosen, A., Bali, M., Horenstein, J. and Akabas, M.H. (2007) Channel opening by general anesthetics and GABA induce similar conformational changes in the GABAA receptor M2 channel-lining segment. Biophy. J. 92:3130-3139.
  34. Qiu A., Min S., Jansen M., Malhotra U., Tsai E., Cabelof D.C., Matherly L., Zhao R., Akabas M.H., Goldman I.D. (2007) Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, response to dietary folate restriction. Am. J. Physiol.- Cell Physiol. 293:C1669-78.
  35. Jansen, M., Bali, M. and Akabas, M.H. (2008) Modular Design of Cys-loop Ligand-gated Ion Channels: Functional 5-HT3 and GABA rho1 Receptors Lacking the Large Cytoplasmic M3M4 Loop. J. Gen. Physiol. 131:137-46.
  36. Zhao R, Qiu A, Tsai E, Jansen M, Akabas MH, Goldman ID. (2008) The Proton-Coupled Folate Transporter (PCFT): Impact on Pemetrexed Transport and on Antifolates Activities as Compared to the Reduced Folate Carrier. Mol Pharmacol. 74:854-62.
  37. Jansen M, Rabe H, Strehle A, Dieler S, Debus F, Dannhardt G, Akabas MH, Luddens H. (2008) Synthesis of GABAA Receptor Agonists and Evaluation of their alpha-Subunit Selectivity and Orientation in the GABA Binding Site. J Med Chem. 51:4430-48.
  38. Cassera, M.B., Hazleton, K.Z., Riegelhaupt, P., Merino, E.F., Luo, M., Akabas, M.H., and Schramm, V.L. (2008) Erythrocytic adenosine monophosphate as alternative source of purines in Plasmodium falciparum. J Biol Chem. 283:32889-32899.
  39. Bali, M., Jansen, M., Akabas, M.H. (2009) GABA-Induced Intersubunit Conformational Movement in the GABAA Receptor alpha1M1-beta2M3 Transmembrane Subunit Interface: Experimental Basis for Homology Modeling of an Intravenous Anesthetic Binding Site. J Neurosci. 29:3083-3092.
  40. Nkrumah, L.J.*, Riegelhaupt, P.M.*, Moura, P., Johnson, D.J., Patel, J., Hayton, K., Ferdig, M.T., Wellems, T.E., Akabas, M.H. and Fidock, D.A. (2009) Probing the multifactorial basis of Plasmodium falciparum quinine resistance: Evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE. Mol. Biochem. Parasitology 165:122-131. *contributed equally
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