I am a post-doctoral research associate at the Albert Einstein College of Medicine (AECOM). My research interests currently include the structure and function of neurotransmitter-gated ion channels at the molecular level, particularly nicotinic acetylcholine receptors, GABA_A receptors and 5-HT₃ receptors. I use a combination of site-directed mutagenesis (SCAM), heterologous expression, immunofluorescence and electrophysiology to study these receptors.

Publications:

Reeves DC, Liebelt DA, Lakshmanan V, Roepe PD, Fidock DA, Akabas MH. (2006) Chloroquine-resistant isoforms of the Plasmodium falciparum chloroquine resistance transporter acidify lysosomal pH in HEK293 cells more than chloroquine-sensitive isoforms. Mol Biochem Parasitol. 150(2):288-99.

Reeves DC, Lummis SC. (2006) Detection of human and rodent 5-HT3B receptor subunits by anti-peptide polyclonal antibodies. BMC Neurosci. 7(1):27.

Reeves DC, Jansen M, Bali M, Lemster T, Akabas MH. (2005) A Role for the beta₁-beta₂ Loop in the Gating of 5-HT3 Receptors. J. Neurosci. Vol. 25, Issue 41, 9358-9366.

Thompson AJ, Price KL, Reeves DC, Chan SL, Chau PL, Lummis SC (2005) Locating an antagonist in the 5-HT3 receptor binding site: A modeling and radioligand binding study. J. Biol. Chem., Vol. 280, Issue 21, 20476-20482.

Goren EN, Reeves DC, Akabas MH. (2004) Loose protein packing around the extracellular half of the GABA(A) receptor beta1 subunit M2 channel-lining segment. J Biol Chem. 279 (12): 11198-205.

Reeves DC, Sayed MFR, PL Chau, Price KL, Lummis SCR. (2003) Prediction of 5-HT₃ Receptor Agonist-Binding Residues Using Homology Modeling. Biophys. J. 84 (4): 2338-2344.

Reeves DC, Lummis SCR. (2002) The molecular basis of the structure and function of the 5-HT3 receptor: a model ligand-gated ion channel. Molecular Membrane Biology. 19: 11-26

Reeves DC, Lummis SCR. (2001). Characterisation of a 5-HT_3B receptor subunit antiserum. Brit. J. Pharmacol. 133(Suppl):188P.

Reeves DC, Goren EN, Akabas MH, Lummis SCR. (2001) Structural and electrostatic properties of the 5-HT3 receptor pore revealed by substituted cysteine accessibility mutagenesis. J. Biol. Chem. 276(45):42035-42.

Reeves DC, Lummis, SCR. (2000) Mutation of an isoleucine residue alters the Ca²⁺ permeability of 5-HT_3A receptors. Brit. J. Pharmacol. 129(Suppl) :39P.

Guppy M, Reeves DC, Bishop T, Withers P, Buckingham J, Brand, MD. (2000) Intrinsic metabolic depression in cells isolated from the hepatopancreas of estivating snails. FASEB J. 14:999-1004.

• Ph.D., 2002, Biochemistry, King's College, Cambridge
• BA/MA, 1998, Natural Sciences, King's College, Cambridge
• GCSE/A Level (All grade A), 1989-1995, King Edward VI Camp Hill School for Boys